Genital Warts caused by HPV – treatment, recurrence, research 2018

What should you know about genital warts caused by HPV?

Anogenital warts typically develop approximately 2–3 months after HPV infection (almost all caused by types 6 or 11); however, not all persons infected with HPV types 6 and 11 develop genital warts. Anogenital warts should be assessed by a clinician and can be treated, although many warts (20–30%) regress spontaneously. Recurrence of anogenital warts within 3 months is common (approximately 30%), whether clearance occurs spontaneously or following treatment.

Read the whole manual about HPV and genital warts:

https://www.cdc.gov/vaccines/pubs/surv-manual/chpt05-hpv.html

What is the most effective treatment against genital warts?

The most effective treatment (with the lowest recurrences) is called Photodynamic Therapy. Unfortunately this treatment is not available in the Western world. I mean: it is possible to get Photodynamic Therapy against i.e. ACNE on face, but it’s not possible to get it against genital warts. Why? I have no idea. Maybe it is a some kind of conspiracy? Anyway the fact is one: HPV virus hides in the skin, and it is possible to eradicate it during a few ALA-PDT treatments.

There were many clinical trials about Photodynamic therapy, but usually in China. You can check this PDF file:

https://www.cdc.gov/std/tg2015/evidence-tables/hpvtableevidence-genitalwarts-2015.pdf

What is the biggest problem with genital warts?

The biggest problem with genital warts is that they can come back, especially in the first months after their show up. All available methods (Cryotherapy, Podophyllotoxin, Aldara, Veregen…) have high recurrence rates.

What can you do to lower genital warts recurrence rate?

You can take medicinal mushrooms to boost your immune system (for example:  Coriolus versicolor and Reishi had 88% clearance rate after 2 months, during one clinical trial).

You can try food supplements like Ellagic Acid and Annona Muricata extract.  In one clinical trial EA+AM gave 74% HPV clearance rate after 6 months.

You can try use Panavir gel topically. Panavir is an antiviral medicine created in Russia. It works antiviral and immunostimulating. There are many russian clinical trials about its effectiveness.

http://poi555.com/2018/01/panavir-from-russia-alternative-treatment-for-hpv-and-genital-warts/

You can try hypethermia (44-45 celsius degree) on your genitals, but it might be hard to get this treatment in any clinic.

You can combine removing warts with taking Inosine Pranobex (3g daily for 4 weeks).

If you have strong recurrences – you should check your glucose level in blood. If you have diabetes, then you should know that there is correlation between the strength of HPV/number of recurrences and diabetes.

So what can you do?

Option A:

You can go to China and try to get Photodynamic Therapy (ALA-PDT) against genital warts. That’s the most expensive option.

Option B:

You can try Cryotherapy or Podophyllotoxin, and be mentally prepared for recurrences.

Option C:

You can try Cryotherapy or Podophyllotoxin, and 1 immune-booster (i.e. medicinal mushrooms, Ellagic acid + Annona Muricata extract)

Option D:

You can try Cryotherapy or Podophyllotoxin, 1 immune-booster and – topically – Panavir gel. Panavir gel should be applied 2 times daily (5 days before the treatment, 10 days after the treatment).

YOU CAN BUY PANAVIR AT OTC ONLINE STORE

Option E:

Combine Cryotherapy or Podophyllotoxin with Inosine Pranobex: 3g daily (1g in the morning/afternoon/evening) for 4 weeks. If you do this, then the chances for recurences are as low as 6-7%.

What about ALDARA?

If you are a man, then it’s a total waste of time.
If you are a woman, then you can try it (it has 60% effectiveness in females).

What about ACV, Thuja, homeopathic medicines?

Forget about it. It’s your health. Don’t waste your time on methods without any clinical trials. You can check Google Scholar and search for clinical trials.

Where to buy medicinal mushrooms? Order mushroom extracts from China

What you should know about medicinal mushroom extracts:

– buy only hot water mushroom extracts OR alcohol mushroom extracts
– avoid powdered mushroom because your body will not digest “chitin”
– avoid powdered mushrooms because they almost don’t have any active ingredients
– hot water extraction is the only way for breaking polysaccharides out of indigestible mushroom cells
– seriously, powdered mushrooms are not better than “placebo”
– only extraction provides concentrated polysaccharides
– only extraction provides good concentration of bioavailable ingredients
– read this article about five major medicinal mushrooms: “Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology”
https://ww.ncbi.wnlm.nih.gov/pmc/articles/PMC4684115/

Where to buy good quality medicinal mushrooms extracts?

There are many companies selling “food suplements” with medicinal mushrooms. Unfortunetly they are extremly overpriced and often contain powdered mushrooms instead of mushroom extracts. Many companies sell products that are not better than “placebo”. It’s because your body will not digest chitin from powdered mushrooms.

Fortunetly you can order mushroom extracts from China.

A few months ago I was looking for a good bio-technology company from China. I’ve requested informations from 15-20 sellers available on AliBaba and AliExpress. That’s how I found XI’AN NATE BIOLOGICAL TECHNOLOGY CO.,LTD.

They gave me the answers to all my questions and they had real knowledge about mushroom extracts. That’s why I decided to buy Coriolus Versicolor (Trametes Versicolor) extract from them. I paid via Western Union and a few days later I got my package, via FedEx, without any problems.

http://www.natesw.com/

That’s why I decided to share my knowledge with you and I asked them for actual price list for all medicinal mushrooms extracts.

Prices below are for 200 kgs, but you can order 1 kg too. Of course the price for 1 kg will be higher.

Item name Specifications / Active ingredients Ref.Qty.kg USD/kg FOB
Chaga mushroom extract (from fruiting body) Polysaccharide>40%,triterpene>2%, Betulinic acid >2% 200kg $ 74.0/kg

Polysaccharide>20%,triterpene>6% 200kg $ 132.0/kg
Reishi mushroom spore powder Wall broken ratio>98% 200kg $55.0/kg
Reishi mushroom extract (from fruiting body) Polysaccharide>30%,triterpenoid>2% 200kg $57.0/kg

Polysaccharide>40%,triterpenoid>2% 200kg $70.0/kg
Polysaccharide>10%,triterpenoid>4% 200kg $86.0/kg
Polysaccharide>10%,triterpenoid>8% 200kg $125.0/kg
Cordycep sinensis extract(CS-4 mycelium) Polysaccharide>30%,Adenosine 0.5 200kg $65.0/kg
 Polysaccharide>40%,Adenosine 1.0 200kg $74.0/kg
Cordyceps militaris extract (from fruiting body) Polysaccharide>40%,Adenosine 0.5 200kg $ 73.0/kg

Polysaccharide>50%,Adenosine 1.0 200kg $ 85.0/kg
Polysaccharide>20%,Cordycepin 1.0% 200kg $ 97.0/kg
Polysaccharide>15%,Cordycepin 3.0% 200kg $ 302.0/kg
Lion’s mane mushroom extract (from fruiting body) Polysaccharide>40% 200kg $ 64.0/kg
 Polysaccharide>50% 200kg $ 75.0/kg
Coriolus versicolor / Turkey tail extract Polysaccharide>40% 200kg $ 65.0/kg
 Glycopeptide 30%,protein 10% 200kg $ 86.0/kg
Shiitake mushroom extract (from fruiting body)

Polysaccharide>40% 200kg $54.0/kg
 Polysaccharide>50% 200kg $62.0/kg
Maitake mushroom extract Polysaccharide>40% 200kg $ 67.0/kg
Maitake mushroom extract MD>30%,Protein10% 200kg

$114.0/kg

Agaricus blazei extract Polysaccharide>40% 200kg $ 55.0/kg
Phellinus igniarius extract (from fruiting body)

Polysaccharide>20%,triterpenoid>1% 200kg

$57.0/kg

 Polysaccharide>40%,triterpenoid>2% 200kg

$99.0/kg

Tremella fuciformis extract Polysaccharide>40% 200kg

$65.0/kg

Enoki mushroom extract Polysaccharide>40% 200kg

$67.0/kg

Coprinus comatus extract Polysaccharide>40% 200kg

$65.0/kg

Agrocybe cylindraceaextract Polysaccharide>40% 200kg

$64.0/kg

Antrodia Camphorata extract Polysaccharide>40% 200kg

$83.0/kg

Poria cocos extract

Polysaccharide>40% 200kg

$54.0/kg

Polyporus umbellatus extract Polysaccharide>40% 200kg

$58.0/kg

AHCC

Alpha-glucan>40%

200kg

$89.0/kg

Agaricus bisporus extract Polysaccharide>40%

200kg

$58.0/kg

Chantarelle extract Polysaccharide>40%

200kg

$56.0/kg

Boletus edulis extract Polysaccharide>40%

200kg

$67.0/kg

HPV treatment – HPV cure research 2018

Prologue: How to deal with HPV?

A) Don’t PANIC!
B) Learn about HPV from reliable sources, for example:
https://www.cdc.gov/vaccines/pubs/surv-manual/chpt05-hpv.html
C) Don’t waste your money on food supplements without any clinical trials (like Echinacea, Astralagus, Zinc…)
D) REALLY DON’T PANIC 🙂

There is no cure for HPV but you can still fight with the virus.

How to get rid of HPV faster?

1) Quit smoking
2) Quit drinking
3) Check glucose level in your blood – there is a correlation between HPV strength/recurrence of genital warts (if you have HPV6/11) and diabetes.
4) Eat healthy food, eat lots of vegetables
5) Lower your sugar/carbohydrates intake. Cancer and HPV love sugar.
6) Exercise 2-3 times per week
7) You can try medicinal mushrooms:
– Coriolus versicolor boost immune system
– Reishi fights directly with HPV* and cancer cells*
– Chaga has strong anti-viral activity

IMPORTANT: buy only alcohol/water reishi extracts because they have active ingredients. Avoid powdered reishi – it’s not better than placebo.

– Lentinan (from shiitake mushrooms) lowers genital warts recurrence

* – In this study, we investigated the effects of the aqueous extracts of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum, obtained from three localities (China; and Morelos and Michoacan, Mexico) on cervical cells transformed by human papillomavirus (HeLa and SiHa) and C-33A cancer cells. The cells were plated in DMEM medium supplemented, and were incubated in the presence of different concentrations of G. lucidum for 24 h. Cell proliferation was determined by MTT colorimetric assay and viability by trypan blue assay. Inhibitory dose was determined (IC50) of the three different extracts of G. lucidum in the culture cell lines mentioned above. The apoptosis process was confirmed by nuclear DNA fragmentation and the cell cycle was determined by flow cytometry. The results showed that aqueous extracts G. lucidum obtained from three localities produced inhibition in the proliferation of VPH transformed cells; they also induced apoptosis and cell cycle arrest in HeLa, SiHa, and C-33A cancer cells. Therefore, it was found that aqueous extracts G. lucidum obtained from three different locations produced inhibitory effect on cancer cells and may have a potential therapeutic use for the prevention and treatment of this disease.

8) Vaccine yourself against HPV – it will not help your current infection, but it can protect you against other HPV strains. The best vaccine is called “Gardasil” and “Gardasil 9”.

How to get rid of genital warts?

You can try:
– Podophyllotoxin (it’s very effective, very fast, but you can get skin infection)
– Imiquimod/Aldara (it’s an immunomodulator, you will wait longer to see the effects; Imiquimod is much less effective in case of men)
– Veregen (it’s a green tea extract, it’s effective but very expensive; you will wait very long to see the effects)
– Panavir (antiviral medicine made in Russia; it’s available i.e. as a gel)
– combine Cryotherapy or Podophyllotoxin with Inosine Pranobex (antiviral medicine)

You can ask your doctor for:
– electrocauterization (it’s painful)
– laser treatment
– cryotherapy (the fastest and the cheapest option)
– photodynamic therapy (the best option but it’s hard to get photodynamic therapy against genital warts; many dermatologists don’t know that photodynamic therapy can be used against genital warts)

In general the best options for HPV are:
– check your glucose level and avoid junk food/sugar
– take medicinal mushrooms – Coriolus versicolor 3g/daily in the morning, Reishi (Lingzhi) 1-2g/daily in the evening.
http://dl.begellhouse.com/journals/708ae68d64b17c52,266d4152107fca7a,3512deba5cc9e72b.html
– take Ellagic acid and Annona Muricata extract (check details below)

In general the best options for HPV genital warts are as above, and additionally:
– use Podophyllotoxin for small warts
– use Cryotherapy for big warts
– try to get Photodynamic Therapy
– try Panavir, it’s very effective in combined therapy, when i.e. Cryotherapy removes the warts, and Panavir lowers the chances of recurrences
– combine Cryotherapy or Podophyllotoxin with Inosine Pranobex

YOU CAN BUY PANAVIR AT OTC ONLINE STORE

2018 UPDATE:

Hyperthermia vs. HPV and genital warts

In the current report, the investigators demonstrate that APOBEC3A and APOBEC3G expression levels are increased in genital warts (condyloma acuminata) compared with normal tissues, in which APOBEC3G is barely detectable (Yang et al., 2017). On heat treatment to 42 °C and 45 °C, there is a significant increase in APOBEC3A and APOBEC3G mRNA transcripts in condyloma acuminate, up to 10-fold. Again, this effect is not observed in normal skin.

Although hyperthermia is not as widely used as cryotherapy in treating warts, including genital warts, it is interesting to note that hyperthermia seems to have an advantage as it is not destructive, but, rather, appears to stimulate antiviral and immunological pathways that are reminiscent of the use of imiquimod. This study provides an elegant explanation for the observed clinical effects of hyperthermia on warts. What is unclear is whether APOBEC3A and APOBEC3G expression contribute not only to editing HPV and limiting its replication, but also whether these mutations increase immune responses against the virus. Hyperthermia, in contrast to cryotherapy, would be an elegant way to expose the virus in a meaningful way to immune reactivity and even prevent recurrences, an effect similar to that of imiquimod when used to treat genital warts.

http://www.sciencedirect.com/science/article/pii/S0022202X17301033

Ellagic acid and Annona Muricata vs. HPV and L-SIL

Ellagic acid (EA) and Annona Muricata (AM) have antioxidant, anticarcinogenic and antiviral activity demonstrated by in vitro models. This pilot study investigated the in vivo potential anti-viral activity in women affected by Low squamous intraepithelial lesion (L-SIL) related to high risk human papilloma virus (HR-HPV), and the ability to modify the oncoproteins expression in the cervical lesion thickness. Sixty women affected by HR-HPV related L-SIL, were randomly divided into two groups: group A (n = 30) supplemented with EA (16 mg) + AM (100 mg) 2 times daily for 6 months and group B (n = 30) administered with placebo. HR-HPV clearance was obtained in 74% of cases in group A compared to 25% of cases in group B (p = 0.001) and p21 expression in LSIL thickness increased in 63.2% of cases in group A compared to 20% in group B (p = 0.03). AE/AM supplementation significantly induces HR-HPV elimination and stimulates p21 expression in LSIL thickness.

http://www.sciencedirect.com/science/article/pii/S1756464617303225

2018 UPDATE 2:

Check clinical trials about Panavir, antiviral medicine made in Russia:

http://poi555.com/2018/01/panavir-from-russia-alternative-treatment-for-hpv-and-genital-warts/

YOU CAN BUY PANAVIR AT OTC ONLINE STORE

2018 UPDATE 3:

Combine Cryotherapy or Podophyllotoxin (to remove warts) with Inosine Pranobex (to lower recurrences):

This study evaluates the effectiveness of immunomodulating drug isoprinosine in a comprehensive treatment of genital warts in men. Most of the patients were aged 20-30 years. The combination therapy was found to have long term effectiveness. In the group of patients undergoing only destructive methods of treatment relapse after 8 month follow-up was diagnosed in 32% and in patients of the combination therapy group (destruction plus isoprinosine) – in 7% of patients. The pharmacological action of the drug (immunostimulating, antiviral) and the effectiveness of its combination with destructive therapies justify the use of inosine pranobex (isoprinosine) both in the complex therapy of genital warts and for the prevention of the disease recurrence.
SOURCE

 

Medicinal mushrooms and cancer – a scientific review

From time immemorial, mushrooms have been valued by humankind as a culinary wonder and folk medicine in Oriental practice. The last decade has witnessed the overwhelming interest of western research fraternity in pharmaceutical potential of mushrooms. The chief medicinal uses of mushrooms discovered so far are as anti-oxidant, anti-diabetic, hypocholesterolemic, anti-tumor, anti-cancer, immunomodulatory, anti-allergic, nephroprotective, and anti-microbial agents. The mushrooms credited with success against cancer belong to the genus Phellinus, Pleurotus, Agaricus, Ganoderma, Clitocybe, Antrodia, Trametes, Cordyceps, Xerocomus, Calvatia, Schizophyllum, Flammulina, Suillus, Inonotus, Inocybe, Funlia, Lactarius, Albatrellus, Russula, and Fomes. The anti-cancer compounds play crucial role as reactive oxygen species inducer, mitotic kinase inhibitor, anti-mitotic, angiogenesis inhibitor, topoisomerase inhibitor, leading to apoptosis, and eventually checking cancer proliferation. The present review updates the recent findings on the pharmacologically active compounds, their anti-tumor potential, and underlying mechanism of biological action in order to raise awareness for further investigations to develop cancer therapeutics from mushrooms. The mounting evidences from various research groups across the globe, regarding anti-tumor application of mushroom extracts unarguably make it a fast-track research area worth mass attention.

Read the whole raport: Recent developments in mushrooms as anti-cancer therapeutics: a review

The best medicinal mushrooms – list, benefits, anti-cancer mushrooms

TOP MEDICINAL MUSHROOMS

  • Reishi
  • Coriolus versicolor
  • Shiitake
  • Monkeyhead mushroom
  • Agaricus blazei
  • Chaga
  • Cordyceps sinensis

Reishi extract

LATIN NAME:
Ganoderma lucideum

PART USED:
Fruitbody, Mycelium

ACTIVE INGREDIENTS:
Polysaccharides, BETA D Glucan, Triterpene, Protein, Reishi acid

PHARMACOLOGICAL ACTION:
Anti-tumor
Protect liver
Anti-aging
Anti-allergic
Strengthen immunity
Promote the synthetic ability of DNA, RNA and protein in the liver, bone marrow and blood

Lions mane / Monkeyhead mushroom extract

LATIN NAME:
Hericium erinaceus

PART USED:
Fruitbody, mycelium

ACTIVE INGREDIENTS:
Polysaccharides, BETA D Glucan, Hericenones

PHARMACOLOGICAL ACTION:
Help to cure dyspesia, gastric ulcer, stomachache gasteremphraxis and neurasthenia
Lower serum cholesterol
Promote blood circulation

Agaricus blazei extract

LATIN NAME:
Agaricus brasilensis

PART USED:
Fruitbody, mycelium

ACTIVE INGREDIENTS:
Polysaccharides, BETA D Glucan, Triterpene, Glycopeptide

PHARMACOLOGICAL ACTION:
Retrain tumor cell growth
Lower blood glucose and cholesterol
Reverse atherosclerosis
Anti-tumor, anti-radiation
Resist mutation and anti-inflammatory

Coriolus versicolor / Turkey Tail

LATIN NAME:
Trametes versicolor

PART USED:
Fruitbody, mycelium

ACTIVE INGREDIENTS:
Polysaccharides, BETA D Glucan, Triterpene, Glycopeptite, Protein

PHARMACOLOGICAL ACTION:
Protect liver and heart
Cure chronic hepatitis and hepatitis B
Anti-aging
Anti-oxidant
Anti-tumor
Enhance body immunity

Shiitake extract

LATIN NAME:
Lentinus edodes

PART USED:
Fruitbody, Mycelium

ACTIVE INGREDIENTS:
Polysaccharides, BETA D Glucan, Adenosine

PHARMACOLOGICAL ACTION:
Relieve symptoms of relapsed gastric cancer, liver cancer, bladder canber.
Enhance body immunity system.
Adjust disorder of trace emements.

Chaga extract

LATIN NAME:
Inonqqus obliquus

PART USED:
Fruitbody, mycelium

ACTIVE INGREDIENTS:
Polysccharides, BETA D Glucan, Triterpene, Betulinic acid

PHARMACOLOGICAL ACTION:
Lower blood glucose
Help to cure heart diseases, diabetes, cancer (gastric cancer, liver cancer, lung cancer)
Restrain HIV virus

Cordyceps sinensis extract

LATIN NAME:
Ophiocordyceps sinensis

PART USED:
Mycelium, dried cordyceps militaris

ACTIVE INGREDIENTS:
Polysaccharides, Manitol, Adenosine, Cordycepin, Cordycepic acid

PHARMACOLOGICAL ACTION:
Improve respiratory system
Enhance body immunity
Promote adrenal gland
Anti-tumor

Medicinal mushrooms vs. cancer – clinical trials

This review discusses the immunological roles of 5 major mushrooms in oncology: Agaricus blazei, Cordyceps sinensis, Grifola frondosa, Ganoderma lucidum, and Trametes versicolor. These mushrooms were selected based on the body of research performed on mushroom immunology in an oncology model. First, this article focuses on how mushrooms modify cytokines within specific cancer models and on how those cytokines affect the disease process. Second, this article examines the direct effect of mushrooms on cancer. Finally, this article presents an analysis of how mushrooms interact with chemotherapeutic agents, including their effects on its efficacy and on the myelosuppression that results from it. For these 5 mushrooms, an abundance of in vitro evidence exists that elucidates the anticancer immunological mechanisms. Preliminary research in humans is also available and is promising for treatment.

Summary of potential clinical applications of medicinal mushrooms:

Type of Cancer Indicated Mushroom
Nonsmall-cell lung cancer Cordyceps
Lung cancer Reishi (ganorderma lucidum)
Gastric cancer PSK (turkey tail/coriolus versicolor)
Hepatocellular carcinoma Agaricus, reishi (ganoderma lucidum)
Leukemia Agaricus, reishi (ganoderma lucidum)
Lymphoma Cordyceps
Breast cancer Reishi, maitake, turkey tail (Coriolus versicolor)
Colon cancer Maitake, reishi, turkey tail (Coriolus versicolor)
Prostate cancer Reishi (ganoderma lucidum)
Sarcoma Reishi (ganoderma lucidum)

Abbreviations:
PSK = polysaccharide K.
Turkey tail = Coriolus versicolor = Trametes versicolor
Reishi = Ganoderma lucidum

Check the whole review below:

Source: Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology

Coriolus versicolor vs. HPV – clinical trials

Study 1:

In the conservative treatment, 64 out of 73 patients (88% of total) reverted to HPV-negative status;
In the combined treatment, 25 out of 27 patients (93% of total)reverted to HPV-negative status;

Study 2:

95% of the patients reverted to HPV-negative status within 6 months;
HPV-positive patients without histological changes reverted to HPV-negative status in 3 months;

Study 3:

Dr Couto showed that Coriolus versicolor biomass supplementation (3 g per day) over a period of one year substantially increased regression of LSIL (72.5% versus control 47.5%) and induced clearance of the high-risk sub-types of the HPV virus responsible for cervical cancer (90.0% versus control 8.5%).

Check this website for more details: Coriolus versicolor as an Effective Addition to the Treatment of HPV Infection

Study 4:

Effect of tropical mushroom, Coriolus versicolor, on natural killer cell

Here, the authors report observation on a patient with underlying breast cancer after complete standard treatment who intake C. versicolor as food supplementation. At first, her natural killer count (CD16/56) was at 5.9% (normal value 6.4-31.1). She got C. versicolor 2400 mg/day for 1 month, and the follow-up result showed CD16/56 equal to 11.6%. This observation can support the findings that C. versicolor could promote immunity.

Source: Annals of Tropical Medicine and Public Health

Coriolus versicolor and Reishi vs. HPV

Coriolus Versicolor (Trametes Versicolor) and Ganoderma Lucidum (Reishi) versus HPV:

This preliminary randomized study investigated the efficacy of medicinal mushrooms, Trametes versicolor (TV), Ganoderma lucidum (GL), and Laetiporus sulphureus (LS), on the clearance of oral human papillomavirus (HPV, serotypes 16 and 18). Among 472 patients who underwent oral swabs for gingivitis, 61 patients were positive for HPV16 or HPV18. Twenty patients were included in group 1 (LS) and 41 patients were included in group 2 (TV+GL) for 2 months. Polymerase chain reaction (PCR) for HPV was performed at inclusion and after 2 months. In group 1, the clearance was equal to 5% after 2 months of treatment. In group 2, the clearance was equal to 88% (P<0.001). The detection of HPV16 or HPV18 could become relevant in routine since positivity is frequent and because a harmless and costless treatment may exist. The use of TV+GL for the clearance of oral HPV deserves further investigation.

Source: Control of oral human papillomavirus (HPV) by medicinal mushrooms, Trametes versicolor and Ganoderma lucidum: a preliminary clinical trial.  2014;16(5):497-8.