HPV การรักษาโรคติดเชื้อเอชพีวี – ทำอย่างไรที่จะรักษาให้หายเร็วขึ้น?

ไมใช่เพียงการรักษาเชื้อเอชพีวีแต่เป็นการต่อสู้ไวรัส

ทำอย่างไรที่จะหายจากเชื้อเอชพีวีอย่างรวดเร็ว?

1) งดสูบบุหรี่
2) งดดื่มแอลกอฮอล์
3) เช็คระดับน้ำตาล (กลูโคส)ในเลือด เนื่องจากมีผลทำให้เกิดหูด ถ้าหากคุณได้รับเชื้อไวรัสเอชพีวี6/11 และเป็นโรคเบาหวาน
4) รับประทานอาหารที่ดีต่อสุขภาพ ทานผักเยอะๆ
5) ลดการบริโภคน้ำตาลและคาร์โบไฮเดรต เพราะว่ามะเร็งและเชื้อเอชพีวีชอบน้ำตาล
6) ออกกำลังกายอย่างน้อย 2-3 ครั้งต่อสัปดาห์
7) รับประทานอาหารเสริมหรือสารสกัดจากเห็ด
– เห็ดอวิ๋นจือ เสริมสร้างระบบภูมิคุ้มกัน
– เห็ดหลินจือ ต่อสู้ทำลายกับเชื้อเอชพีวีและเซลล์มะเร็งโดยตรง
– เห็ดหอม ยับยั้งการเจริญเติบโตของหูด

ข้อสำคัญ : ซื้อเฉพาะสารสกัดเห็ดหลินจือ หรือน้ำสกัดเห็ดหลินจือเท่านั้น จึงจะออกฤทธิ์ดีที่สุด หลีกเลี่ยงการใช้ผงเห็ดซึ่งไม่มีฤทธิ์รักษษโรค

ยกตัวอย่างวิธีทาน:
– รับประทาน เห็ดอวิ๋นจือ3-4 กรัม หลังอาหาร ในตอนเช้า
– รับประทาน เห็ดหลินจือ 1-2 กรัม ในตอนเย็น

8) ฉีดวัคซีนต้านเชื้อเอชพืวี ซึ่งไม่ได้ช่วยอะไรหากคนติดเชื้อแล้ว แต่สามารถต่อต้านเชื้อเอชพีวีสายพันธุ์อื่น วัคซีนที่ดีที่สุด กราดาซิล (Gardasil) และ กราดาซิล 9

ทำอย่างไรไม่ให้เกิดหูด?

แนะนำทดลองใช้:
– Podophyllotoxin ยาโพโดฟิลโลทอกซิน ฤทธิ์ต่อต้านการแบ่งตัวของเซลล์ แต่สามารถติดเชื้อได้อีก
– Imiquimod/Aldara ยาอิมิควิโมดหรืออัลดารา ใช้เป็นยาที่กระตุ้นภูมิคุ้มกันต้านทานโรคของร่างกายให้ตอบสนองต่อการเจริญเติบโตที่ผิดปกติของผิว ซึ่งอาจจะเห็นผลช้า
– Veregen เวเรเจน เป็นสารสกัดจากชาเขียว ให้ผลสัมฤทธิ์ดี ใช้เวลานานจึงจะเห็นผมและมีราคาแพง

ปรึกษาหรือสอบถามคุณหมอที่ดูแลคุณ
– การจี้ด้วยไฟฟ้า ซึ่งจะระคายเคืองและแสบบริเวณที่จี้
– การรักษาด้วยการยิงเลเซอร์
– การบำบัดด้วยความเย็นจัด เห็นผลเร็วและราคาถูก
– โฟโต้ไดนามิค เทอราปี เป็นกระบวนการใช้แสงกระตุ้นการออกฤทธิ์ของสารละลายชนิดพิเศษที่ทาลงบนผิว เป็นการเร่งปฏิกิริยาเคมี ต่อต้านการเกิดหูด

โดยสรุปวิธีที่ดีที่สุดในการรักษาเอชพีวี
– เช็คระดับน้ำตาล (กลูโคส) และหลีกเลี่ยงอาหารจั๊งค์ฟู้ด
– ทานผลิตภัณฑ์ตัวยาที่ทำจากเห็ด

เพิ่มเติมจากที่ได้กล่าวไว้แล้ว เพื่อกำจัดหูดออกไป
– ใช้ ยาโพโดฟิลโลทอกซิน สำหรับบริเวณหูดตุ่มเล็กๆ
– ใช้การบำบัดด้วยความเย็นจัดกำจัดหูดขนาดใหญ่
– ทดลองใช้โฟโต้ไดนามิค เทอราปี

Natural HPV treatment: Ellagic acid and Annona Muricata – strong antiviral herbs

It seems that we have a new natural treatment for HPV infections.

Journal of Functional Foods published article “Antiviral activity of Ellagic acid and Annona Muricata in cervical HPV related pre-neoplastic lesions: A randomized trial” about Ellagic acid and Annona Muricata, two natural ingredients that fights with HPV virus:

Ellagic acid (EA) and Annona Muricata (AM) have antioxidant, anticarcinogenic and antiviral activity demonstrated by in vitro models. This pilot study investigated the in vivo potential anti-viral activity in women affected by Low squamous intraepithelial lesion (L-SIL) related to high risk human papilloma virus (HR-HPV), and the ability to modify the oncoproteins expression in the cervical lesion thickness. Sixty women affected by HR-HPV related L-SIL, were randomly divided into two groups: group A (n = 30) supplemented with EA (16 mg) + AM (100 mg) 2 times daily for 6 months and group B (n = 30) administered with placebo. HR-HPV clearance was obtained in 74% of cases in group A compared to 25% of cases in group B (p = 0.001) and p21 expression in LSIL thickness increased in 63.2% of cases in group A compared to 20% in group B (p = 0.03). AE/AM supplementation significantly induces HR-HPV elimination and stimulates p21 expression in LSIL thickness.

See the whole article:

http://www.sciencedirect.com/science/article/pii/S1756464617303225

So as for now we have at least 2 very effective natural treatments for HPV:
– mushroom extracts from Coriolus Versicolor + Reishi, 88% clearance after 2 months
– Ellagic acid and Annona Muricata, 74% clearance after 6 months

More informations about ellagic acid:

Ellagic acid is a Polyphenol compound found in numerous fruits and vegetables, including, raspberries; strawberries; cranberries; walnuts; pecans; pomegranates; and other plant foods. It is often regarded as an antioxidant. Ellagic Acid Clinical Tests on cultured human cells also show that Ellagic acid prevents the destruction of the p53 gene by cancer cells. Additional studies suggest that one of the mechanisms by which Ellagic acid inhibits mutagenesis and carcinogenesis is by forming adducts with DNA, thus masking binding sites to be occupied by the mutagen or carcinogen.

https://pubchem.ncbi.nlm.nih.gov/compound/ellagic_acid#section=Top

Remember to use EXTRACTS because they have high amounts of active ingredients.

The Strongest Antiviral Mushrooms: Reishi and Chaga – HPV treatment 2018

Reishi mushroom extracts contains such active ingredients as:
– polysaccharides
– triterpenes

Chaga mushroom extracts contains such active ingredients as:
– polysaccharides
– triterpenes
– betulinic acid

Remember to use ONLY WATER EXTRACTS or ALCOHOL EXTRACTS. Avoid “powdered mushrooms” – you can’t digest chitin and – even if – they have very, very little active ingredients.

Antioxidant polysaccharides

Polysaccharides from mushrooms including Pleurotus eryngii, P. ostreatus, P. nebrodensis, Lentinus edodes, Hypsizygus marmoreus, Flammulina velutipes, Ganoderma lucidum, and Hericium erinaceus were isolated by water extraction and alcohol precipitation. Our results suggest that all tested polysaccharides have the significant antioxidant capacities of scavenging free radicals (1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals). Among them, the H. erinaceus polysaccharide exhibits the highest 1,1-diphenyl-2-picrylhydrazyl radical-scavenging activity, whereas the L. edodes polysaccharide shows the strongest scavenging ability for hydroxyl radicals. Furthermore, using the MCF-7 breast cancer cell line and HeLa cells, all 8 selected polysaccharides are able to inhibit the proliferation of tumor cells, but the strength of inhibition varied depending on the mushroom species and the concentration used. Notably, G. lucidum polysaccharide shows the highest inhibition activity on MCF-7 cells. By comparison, H. erinaceus polysaccharide has the strongest inhibitory effect on HeLa cells. Moreover, high-performance liquid chromatography with a carbohydrate analysis column showed significant differences in polysaccharide components among these mushrooms. Thus our data suggest that the different species of mushrooms have the variable functions because of their own specific polysaccharide components. The 8 mushroom polysaccharides have the potential to be used as valuable functional food additives or sources of therapeutic agents for antioxidant and cancer treatments, especially polysaccharides from H. erinaceus, L. edodes, and G. lucidum.

http://dl.begellhouse.com/journals/708ae68d64b17c52,7b35b5ed6bb0a817,0d63c11a3ff8f73e.html

Reishi  (Ganoderma lucidum) vs. HPV

This preliminary randomized study investigated the efficacy of medicinal mushrooms, Trametes versicolor (TV), Ganoderma lucidum (GL), and Laetiporus sulphureus (LS), on the clearance of oral human papillomavirus (HPV, serotypes 16 and 18). Among 472 patients who underwent oral swabs for gingivitis, 61 patients were positive for HPV16 or HPV18. Twenty patients were included in group 1 (LS) and 41 patients were included in group 2 (TV+GL) for 2 months. Polymerase chain reaction (PCR) for HPV was performed at inclusion and after 2 months. In group 1, the clearance was equal to 5% after 2 months of treatment. In group 2, the clearance was equal to 88% (P<0.001). The detection of HPV16 or HPV18 could become relevant in routine since positivity is frequent and because a harmless and costless treatment may exist. The use of TV+GL for the clearance of oral HPV deserves further investigation.

http://dl.begellhouse.com/journals/708ae68d64b17c52,266d4152107fca7a,3512deba5cc9e72b.html

Reishi vs. bacteria

This article presents a comparative gas chromatography (GC)−mass spectrometry (MS)−based metabolomic analysis of mycelia and fruiting bodies of the medicinal mushroom Ganoderma lucidum. Three aqueous extracts−mycelia, fruiting bodies, and a mixture of them−and their sequential fractions (methanolic and ethyl acetate), prepared using an accelerated solvent extractor, were characterized by GC-MS to determine volatile organic compounds and by high-performance thin-layer chromatography to quantify ascorbic acid, a potent antioxidant. In addition, these extracts and fractions were assessed against Candida albicans and C. glabrata biofilms via the XTT reduction assay, and their antioxidant potential was evaluated. Application of chemometrics (hierarchical cluster analysis and principal component analysis) to GC data revealed variability in volatile organic compound profiles among G. lucidum extracts and fractions. The mycelial aqueous extract demonstrated higher anti-Candida activity and ascorbic acid content among all the extracts and fractions. Thus, this study illustrates the preventive effect of G. lucidum against C. albicans and C. glabrata biofilms along with its nutritional value.

http://dl.begellhouse.com/journals/708ae68d64b17c52,32c8651274405055,16650dfe7395ce6b.html

Reishi vs. cancer

In this study, we investigated the effects of the aqueous extracts of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum, obtained from three localities (China; and Morelos and Michoacan, Mexico) on cervical cells transformed by human papillomavirus (HeLa and SiHa) and C-33A cancer cells. The cells were plated in DMEM medium supplemented, and were incubated in the presence of different concentrations of G. lucidum for 24 h. Cell proliferation was determined by MTT colorimetric assay and viability by trypan blue assay. Inhibitory dose was determined (IC50) of the three different extracts of G. lucidum in the culture cell lines mentioned above. The apoptosis process was confirmed by nuclear DNA fragmentation and the cell cycle was determined by flow cytometry. The results showed that aqueous extracts G. lucidum obtained from three localities produced inhibition in the proliferation of VPH transformed cells; they also induced apoptosis and cell cycle arrest in HeLa, SiHa, and C-33A cancer cells. Therefore, it was found that aqueous extracts G. lucidum obtained from three different locations produced inhibitory effect on cancer cells and may have a potential therapeutic use for the prevention and treatment of this disease.

http://dl.begellhouse.com/journals/708ae68d64b17c52,3fd456332214676c,029d31540328ce6b.html

Reishi vs. tumors

Ganoderma lucidum has been established to be an antitumor natural product. Hot-water extracts of the mycelium of G. lucidum (GLP) exhibited antitumor effect against fibrosarcoma in male and female C3H mice and inhibited the metastasis of the tumor to the lung. Moreover, we have fractionated GLP into polysaccharide fraction [GLP(AI)] and nonpolysaccharide fraction. We found that GLP(AI) is the major component to show the in vivo antitumor effect on fibrosarcoma growth in C3H mice. The effect of PS-G purified from GLP(AI) by Sephadex and ion-exchange column chromatography on the induction of differentiation in leukemic U937 cells was examined. We found that it could stimulate blood mononuclear cells to secrete cytokines, TNF-a, IFN-g, IL-1b, and IL-6, etc., which were both antiproliferative and differentiation-inductive to the leukemic U937 and HL-60 cells. TNF-a and IFN-g, especially, induced apoptosis and differentiation in the treated leukemic cells. Furthermore, antitumor activity of G. lucidum on intraperitioneally implanted Lewis lung carcinoma in syngeneic C57BL/6 mice was investigated. The results showed that GLP significantly increased the lifespan of tumor-implanted mice, when administered intraperioneally alone or in combination with cytotoxic antitumor drugs (adriamycin, fluorouracil, thioguanine, methotrexate, or cisplatin) or a synthetic immunomodulator (imexon). The GLP was not cytotoxic to cultured cells, and the antitumor activity was abolished by pretreatment of mice with cyclosporine. These observations suggest that GLP exerts its antitumor effect mainly through immunopotentiation of the tumor-bearing animals.

http://dl.begellhouse.com/journals/708ae68d64b17c52,58cadf0c6c913237,1af485045b17e424.html

Betulinic acid from Chaga mushrooms

Betulinic Acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial apogenic factors, activation of caspases, and DNA fragmentation. Although originally thought to exhibit specific cytotoxicity against melanoma cells, this agent has been found to be cytotoxic against non-melanoma tumor cell types including neuroectodermal and brain tumor cells.

https://pubchem.ncbi.nlm.nih.gov/compound/betulinic_acid#section=Top

Chaga vs. cancer

The natural compound betulinic acid shows potent anticancer activity through activation of the mitochondrial pathway of apoptosis in cancer cells. Betulinic acid may also be used in combination protocols to enhance its antitumor activity, for example with chemo- or radiotherapy or with the death receptor ligand TRAIL. Because of its relative selective cytotoxicity against malignant compared to normal cells, betulinic acid is a promising new experimental anticancer agents for the treatment of human cancers.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658785/

NieR: Automata – overrated, repetive and boring PS4 / PC / STEAM / GOTY 2017

NieR: Automata is one of the most overrated games of 2017 year.

Why?

– it’s not a RPG game
– it doesn’t have an open world
– it looks like PlayStation 2 game with better looking models of the main heroes
– environments are simple and repetive
– the rebels in Rebel camp looks very primitive
– the story is really simple and short
– the story is not better than stories from cheap S-F books
– quests and side quests are short and boring
+ the fighting looks impressive
+ the music is awesome
+ overall it’s not a bad game, but 8-9/10 ratings are a terrible joke

You can enjoy this game only if you will focus on brainless fighting. In other case you will be really, really bored.

5/10

Maitake (Grifola frondosa) vs. cancer

Maitake D (MD)-Fraction is a highly purified soluble β-glucan derived from Grifola frondosa (an oriental edible mushroom). Intraperitoneal (i.p.) injection of MD-Fraction has been reported to inhibit tumor growth via enhancement of the host immune system. In this study, we demonstrated that oral administration of MD-Fraction as well as i.p. injection significantly inhibited tumor growth in murine tumor models. After oral administration, MD-Fraction was not transferred to the blood in its free form but was captured by antigen-presenting cells such as macrophages and dendritic cells (DCs) present in the Peyer’s patch. The captured MD-Fraction was then transported to the spleen, thereby inducing the systemic immune response. Our study showed that MD-Fraction directly induced DC maturation via a C-type lectin receptor dectin-1 pathway. The therapeutic response of orally administered MD-Fraction was associated with (i) induced systemic tumor-antigen specific T cell response via dectin-1-dependent activation of DCs, (ii) increased infiltration of the activated T cells into the tumor and (iii) decreased number of tumor-caused immunosuppressive cells such as regulatory T cells and myeloid-derived suppressor cells. Our preclinical study suggests that MD-Fraction is a useful oral therapeutic agent in the management of patients with cancer.

In summary, our results demonstrated that orally administered MD-Fraction inhibits tumor growth by (i) inducing the systemic tumor-antigen specific T cell response via the dectin-1 dependent activation of DCs, (ii) increasing the infiltration of the activated T cells into the tumor and (iii) decreasing tumor-linked immunosuppressive elements such as Tregs and MDSCs. Our preclinical study advocates the implementation of MD-Fraction as an oral therapeutic agent in the management of patients with cancer.

http://onlinelibrary.wiley.com/doi/10.1002/ijc.27999/full

Where to buy big size shoes, T-shirts and polos in Bangkok? MBK, Bobae Tower, Decathlon

Where to buy big size shoes (for work) in Bangkok?

1. Take BTS train to National Statium.
2. Use the pedestrain bridge to walk into MBK.

On the ground floor there are a few shops with big size shoes.

Where to buy big size shoes (for daily life) in Bangkok?

1. Take MRT train to Queen Sirikit National Convention Centre MRT station.
2. Take moto taxi to TESCO shopping mall.
3. Inside TESCO shopping mall look for DECATHLON shop.
4. You can buy big size shoes (44, 45, 46, 47) in very attractive prices.

Where to buy big size shirts and polos in Bangkok?

1. Take MRT train to Hua Lamphong MRT station.
2. Take exit to the Hua Lamphong train station.
3. Take taxi to Bobae Tower.

Bobae Tower is a big, wholesale, clothing market. You can get big size shirts and polos in attractive prices. If you are looking for big shirts and polos, you can take the elevator to the level with the food park. You will find there many shops offering XL, XXL, XXXL and XXXXL shirts.

Medicinal mushrooms: Reishi / Linghzi vs. Hepatitis B, cancer, tumors, inflammation

Reishi vs. Hepatitis B

The polysaccharide fractions and triterpenes isolated from Ganoderma lucidum have shown protection effects on the liver in animal studies. This double-blind, randomised, and multicentered study aimed to evaluate the safety and effect of a G. lucidum extraction, Ganopoly, in chronic hepatitis B. Ninety patients with chronic hepatitis B, hepatitis В viral (HBV) DNA positivity, and aminotransferase elevation were included in this multicenter prospective randomized Phase I/II study. Patients were randomized to be given Ganopoly (n = 60) or placebo (n = 30) for 12 weeks, then followed up for 13 weeks. Effect of therapy on levels of HBV DNA and aminotransferase activities in serum and hepatitis В е antigen (HBeAg) status were investigated. There were 78 assessable patients who entered the trial for efficacy and safety; 13 of 52 (25%) patients receiving Ganopoly responded by reducing HBeAg and HBV DNA, compared to 1 of 26 (4%) in the control group (P < 0.05). Among those with serum aspartate aminotransferase (AST) values < 100 U/L (n = 29), 41% (12/29) responded, and among those with AST values > 100 U/L (n = 23), 65% (15/23) responded. Within the 6-month study period, 33% (17/ 52) of treated patients had normal aminotransferase (ALT) values, and 13% (7/52) had cleared hepatitis B surface antigen (HBsAg) from serum, whereas none of the controls had normal ALT values or had lost HBsAg. Eight of 60 patients in Ganopoly group and 4 of 30 in the controls were unable to be followed up due to loss or withdrawal. Our study indicates that Ganopoly is well tolerated and appears to be active against HBV in patients with chronic hepatitis B.

http://www.dl.begellhouse.com/journals/708ae68d64b17c52,72e968661ff5d957,09001a9418679e96.html

Reishi vs. Hepatitis B (II)

Herbal medicines are always considered to be a safe and useful approach for the treatment of chronic hepatopathy. Ganoderma luciudm (Curt.:Fr.) P. Karst. [(Ling Zhi, Reishi mushroom) (Aphyllophoromycetideae)], a highly ranked medicinal mushroom in Oriental traditional medicine, has been widely used for the treatment of chronic hepatopathy of various etiologies. Data from in vitro and animal studies indicate that G. lucidum extracts (mainly polysaccharides or triterpenoids) exhibit protective activities against liver injury induced by toxic chemicals (e.g., CCl4) and Bacillus Calmette-Guerin (BCG) plus lipopolysaccharide (LPS). G. lucidum also showed anti–hepatitis B virus (HBV) activity in a duckling study. Recently, a randomized placebo-controlled clinical study showed that treatment with G. lucidum polysaccharides for 12 weeks reduced hepatitis B e antigen (HBeAg) and HBV DNA in 25% (13/52) patients with HBV infection. The mechanisms of the hepatoprotective effects of G. lucidum have been largely undefined. However, accumulating evidence suggests several possible mechanisms. These include antioxidant and radical-scavenging activity, modulation of hepatic Phase I and II enzymes, inhibition of b-glucuronidase, antifibrotic and antiviral activity, modulation of nitric oxide production, maintenance of hepatocellular calcium homeostasis, and immunomodulating effects. G. lucidum could represent a promising approach for the management of various chronic hepatopathies. Further studies are needed to explore the kinetics and mechanisms of action of G. lucidum constituents with hepatoprotective activities.

http://www.dl.begellhouse.com/journals/708ae68d64b17c52,3389befb6be7818a,3ea891d772a09d0f.html

Reishi vs. tumors

Ganoderma lucidum has been established to be an antitumor natural product. Hot-water extracts of the mycelium of G. lucidum (GLP) exhibited antitumor effect against fibrosarcoma in male and female C3H mice and inhibited the metastasis of the tumor to the lung. Moreover, we have fractionated GLP into polysaccharide fraction [GLP(AI)] and nonpolysaccharide fraction. We found that GLP(AI) is the major component to show the in vivo antitumor effect on fibrosarcoma growth in C3H mice. The effect of PS-G purified from GLP(AI) by Sephadex and ion-exchange column chromatography on the induction of differentiation in leukemic U937 cells was examined. We found that it could stimulate blood mononuclear cells to secrete cytokines, TNF-a, IFN-g, IL-1b, and IL-6, etc., which were both antiproliferative and differentiation-inductive to the leukemic U937 and HL-60 cells. TNF-a and IFN-g, especially, induced apoptosis and differentiation in the treated leukemic cells. Furthermore, antitumor activity of G. lucidum on intraperitioneally implanted Lewis lung carcinoma in syngeneic C57BL/6 mice was investigated. The results showed that GLP significantly increased the lifespan of tumor-implanted mice, when administered intraperioneally alone or in combination with cytotoxic antitumor drugs (adriamycin, fluorouracil, thioguanine, methotrexate, or cisplatin) or a synthetic immunomodulator (imexon). The GLP was not cytotoxic to cultured cells, and the antitumor activity was abolished by pretreatment of mice with cyclosporine. These observations suggest that GLP exerts its antitumor effect mainly through immunopotentiation of the tumor-bearing animals.

http://www.dl.begellhouse.com/journals/708ae68d64b17c52,58cadf0c6c913237,1af485045b17e424.html

Reishi vs. tumors and inflammation

A series of lanostane-type triterpene acids, including eleven lucidenic acids (3, 4, 9, 10, 13–19) and six ganoderic acids (20–22, 24, 26, 27), as well as six sterols (28–33), all isolated from the fruiting bodies of the fungus Ganoderma lucidum, were examined for their inhibitory effects on the induction of Epstein–Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, a known primary screening test for anti-tumor promoters. All of the compounds tested, except for ganolactone (27) and three sterols (29–31), showed potent inhibitory effects on EBV-EA induction, with IC50 values of 235–370 mol ratio/32 pmol TPA. In addition, nine lucidenic acids (1, 2, 5–8, 11, 12, 18) and four ganoderic acids (20, 23–25) were found to inhibit TPA-induced inflammation (1 μg/ear) in mice, with ID50 values of 0.07–0.39 mg per ear. Further, 20-hydroxylucidenic acid N (18) exhibited inhibitory effects on skin-tumor promotion in an in vivo two-stage mouse-skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as promoter.

http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790027/full

Reishi vs. cancer

The meta-analysis results showed that patients who had been given G. lucidum alongside with chemo/radiotherapy were more likely to respond positively compared to chemo/radiotherapy alone (RR 1.50; 95% CI 0.90 to 2.51, P = 0.02). G. lucidum treatment alone did not demonstrate the same regression rate as that seen in combined therapy. The results for host immune function indicators suggested that G. lucidum simultaneously increases the percentage of CD3, CD4 and CD8 by 3.91% (95% CI 1.92% to 5.90%, P < 0.01), 3.05% (95% CI 1.00% to 5.11%, P < 0.01) and 2.02% (95% CI 0.21% to 3.84%, P = 0.03), respectively. In addition, leukocyte, NK-cell activity and CD4/CD8 ratio were marginally elevated. Four studies showed that patients in the G. lucidum group had relatively improved quality of life in comparison to controls. One study recorded minimal side effects, including nausea and insomnia. No significant haematological or hepatological toxicity was reported.

Our review did not find sufficient evidence to justify the use of G. lucidum as a first-line treatment for cancer. It remains uncertain whether G. lucidum helps prolong long-term cancer survival. However, G. lucidum could be administered as an alternative adjunct to conventional treatment in consideration of its potential of enhancing tumour response and stimulating host immunity. G. lucidum was generally well tolerated by most participants with only a scattered number of minor adverse events. No major toxicity was observed across the studies. Although there were few reports of harmful effect of G. lucidum, the use of its extract should be judicious, especially after thorough consideration of cost-benefit and patient preference. Future studies should put emphasis on the improvement in methodological quality and further clinical research on the effect of G. lucidum on cancer long-term survival are needed. An update to this review will be performed every two years.

http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007731.pub3/full

Where to buy medicinal mushrooms? Order mushroom extracts from China

What you should know about medicinal mushroom extracts:

– buy only hot water mushroom extracts OR alcohol mushroom extracts
– avoid powdered mushroom because your body will not digest “chitin”
– avoid powdered mushrooms because they almost don’t have any active ingredients
– hot water extraction is the only way for breaking polysaccharides out of indigestible mushroom cells
– seriously, powdered mushrooms are not better than “placebo”
– only extraction provides concentrated polysaccharides
– only extraction provides good concentration of bioavailable ingredients
– read this article about five major medicinal mushrooms: “Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology”
https://ww.ncbi.wnlm.nih.gov/pmc/articles/PMC4684115/

Where to buy good quality medicinal mushrooms extracts?

There are many companies selling “food suplements” with medicinal mushrooms. Unfortunetly they are extremly overpriced and often contain powdered mushrooms instead of mushroom extracts. Many companies sell products that are not better than “placebo”. It’s because your body will not digest chitin from powdered mushrooms.

Fortunetly you can order mushroom extracts from China.

A few months ago I was looking for a good bio-technology company from China. I’ve requested informations from 15-20 sellers available on AliBaba and AliExpress. That’s how I found XI’AN NATE BIOLOGICAL TECHNOLOGY CO.,LTD.

They gave me the answers to all my questions and they had real knowledge about mushroom extracts. That’s why I decided to buy Coriolus Versicolor (Trametes Versicolor) extract from them. I paid via Western Union and a few days later I got my package, via FedEx, without any problems.

http://www.natesw.com/

That’s why I decided to share my knowledge with you and I asked them for actual price list for all medicinal mushrooms extracts.

Prices below are for 200 kgs, but you can order 1 kg too. Of course the price for 1 kg will be higher.

Item name Specifications / Active ingredients Ref.Qty.kg USD/kg FOB
Chaga mushroom extract (from fruiting body) Polysaccharide>40%,triterpene>2%, Betulinic acid >2% 200kg $ 74.0/kg

Polysaccharide>20%,triterpene>6% 200kg $ 132.0/kg
Reishi mushroom spore powder Wall broken ratio>98% 200kg $55.0/kg
Reishi mushroom extract (from fruiting body) Polysaccharide>30%,triterpenoid>2% 200kg $57.0/kg

Polysaccharide>40%,triterpenoid>2% 200kg $70.0/kg
Polysaccharide>10%,triterpenoid>4% 200kg $86.0/kg
Polysaccharide>10%,triterpenoid>8% 200kg $125.0/kg
Cordycep sinensis extract(CS-4 mycelium) Polysaccharide>30%,Adenosine 0.5 200kg $65.0/kg
 Polysaccharide>40%,Adenosine 1.0 200kg $74.0/kg
Cordyceps militaris extract (from fruiting body) Polysaccharide>40%,Adenosine 0.5 200kg $ 73.0/kg

Polysaccharide>50%,Adenosine 1.0 200kg $ 85.0/kg
Polysaccharide>20%,Cordycepin 1.0% 200kg $ 97.0/kg
Polysaccharide>15%,Cordycepin 3.0% 200kg $ 302.0/kg
Lion’s mane mushroom extract (from fruiting body) Polysaccharide>40% 200kg $ 64.0/kg
 Polysaccharide>50% 200kg $ 75.0/kg
Coriolus versicolor / Turkey tail extract Polysaccharide>40% 200kg $ 65.0/kg
 Glycopeptide 30%,protein 10% 200kg $ 86.0/kg
Shiitake mushroom extract (from fruiting body)

Polysaccharide>40% 200kg $54.0/kg
 Polysaccharide>50% 200kg $62.0/kg
Maitake mushroom extract Polysaccharide>40% 200kg $ 67.0/kg
Maitake mushroom extract MD>30%,Protein10% 200kg

$114.0/kg

Agaricus blazei extract Polysaccharide>40% 200kg $ 55.0/kg
Phellinus igniarius extract (from fruiting body)

Polysaccharide>20%,triterpenoid>1% 200kg

$57.0/kg

 Polysaccharide>40%,triterpenoid>2% 200kg

$99.0/kg

Tremella fuciformis extract Polysaccharide>40% 200kg

$65.0/kg

Enoki mushroom extract Polysaccharide>40% 200kg

$67.0/kg

Coprinus comatus extract Polysaccharide>40% 200kg

$65.0/kg

Agrocybe cylindraceaextract Polysaccharide>40% 200kg

$64.0/kg

Antrodia Camphorata extract Polysaccharide>40% 200kg

$83.0/kg

Poria cocos extract

Polysaccharide>40% 200kg

$54.0/kg

Polyporus umbellatus extract Polysaccharide>40% 200kg

$58.0/kg

AHCC

Alpha-glucan>40%

200kg

$89.0/kg

Agaricus bisporus extract Polysaccharide>40%

200kg

$58.0/kg

Chantarelle extract Polysaccharide>40%

200kg

$56.0/kg

Boletus edulis extract Polysaccharide>40%

200kg

$67.0/kg

Alternative HPV treatments / cure research / clinical trials 2018

Photodynamic Therapy

Photodynamic therapy (PDT), sometimes called photochemotherapy, is a form of phototherapy involving light and a photosensitizing chemical substance, used in conjunction with molecular oxygen to elicit cell death (phototoxicity). PDT has proven ability to kill microbial cells, including bacteria, fungi and viruses. PDT is popularly used in treating acne. It is used clinically to treat a wide range of medical conditions, including wet age-related macular degeneration, psoriasis, atherosclerosis and has shown some efficacy in anti-viral treatments, including herpes. It also treats malignant cancers including head and neck, lung, bladder and particular skin. The technology has also been tested for treatment of prostate cancer, both in a dog model and in prostate cancer patients. It is recognised as a treatment strategy that is both minimally invasive and minimally toxic. (Wikipedia)

In case of genital warts / cancer caused by HPV it is possible to use Photodynamic Therapy (PDT) with 5-aminolevulinic acid (ALA). It’s called ALA-PDT.

For more informations check this PDF file, page no. 14 and following pages:
https://www.cdc.gov/std/tg2015/evidence-tables/hpvtableevidence-genitalwarts-2015.pdf

Immunotherapy with Virus Like Particles (VLPs)

Genital warts are caused by infection with human papillomavirus type 6 (HPV6) or less commonly the closely related HPV 11.1,2 While benign, these lesions commonly persist, with less than half of immunocompetent patients resolving infection within six months.3 Despite use of destructive therapies including electrocautery, cryotherapy, or application of podophyllotoxin or trichloroacetic acid, disease recurrence is common.4 However, generation of specific immunity to papillomavirus proteins appears important for clearance, as immunosuppressed individuals with impaired cell mediated immunity clear genital warts more slowly, and more commonly have recurrence after treatment.5

The major papillomavirus protein L1 self assembles into virus like particles, which, together with alum based adjuvants, are the basis of vaccines licensed for use for prevention of HPV infection. L1 virus like particles, in animal models, can induce strong cell mediated immune responses including cytotoxic T-cell responses if delivered without adjuvant. A phase 1 open label safety trial of unadjuvanted HPV6 VLPs (VLP immunotherapy) in patients with treatment refractory genital warts had observed regression of disease that would not have been expected from previous studies of therapy in similar patients.9 Therefore a randomized placebo controlled trial was undertaken to establish whether VLP immunotherapy could reduce the recurrence of genital warts following locally destructive therapy.

Read the whole article:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495719/

Lopimune (Lopinavir/Ritonavir) as a Treatment for HPV-Related Pre-Invasive Cervical Disease

A total of 23 women with HSIL were treated with Lopimune during which time no adverse reactions were reported. A maximum concentration of 10 ng/ml of lopinavir was detected in patient plasma 1 week after starting treatment. HPV was no longer detected in 12/23 (52.2%, 95%CI: 30.6–73.2%). Post-treatment cytology at 12 weeks on women with HSIL, showed 14/22 (63.6%, 95%CI: 40.6–82.8%) had no dysplasia and 4/22 (18.2%, 95%CI: 9.9–65.1%) were now low grade demonstrating a combined positive response in 81.8% of women of which 77.8% was confirmed by histology. These data are supported by colposcopic images, which show regression of cervical lesions.

Read the whole article:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147917

Panavir – antiviral medicine from Russia

Panavir – biologically active substance of Panavir is ”GG17” – plant polysaccharide, relating tohexose glycoside class. It main dosage form – intravenous solution 0,004% in 5 ml ampoules (single therapeutic dose). Additional dosage form: rectal suppositories, vaginal suppositories, gel for outward application. Preparation has original pharmacologic property, non-toxic in therapeutic dose (LD50 ~ 3000 therapeutic dose). It is successfully used where ordinary antiviral preparations are not effective or contraindicative or have unsatisfactorily effect: chronic tick-borne encephalitis, ophthalmoherpes, herpes zoster (shingles), cytomegalovirus, Epstein-Barr virus, Human papilloma virus. Now Panavir tests for treatment chronic hepatitis B and C.

Read the whole article:
http://poi555.com/2018/01/panavir-from-russia-alternative-treatment-for-hpv-and-genital-warts/

Combined therapy: remove genital warts + use Inosine Pranobex

This study evaluates the effectiveness of immunomodulating drug isoprinosine in a comprehensive treatment of genital warts in men. Most of the patients were aged 20-30 years. The combination therapy was found to have long term effectiveness. In the group of patients undergoing only destructive methods of treatment relapse after 8 month follow-up was diagnosed in 32% and in patients of the combination therapy group (destruction plus isoprinosine) – in 7% of patients. The pharmacological action of the drug (immunostimulating, antiviral) and the effectiveness of its combination with destructive therapies justify the use of inosine pranobex (isoprinosine) both in the complex therapy of genital warts and for the prevention of the disease recurrence.

Source