PL: HPV – profilaktyka i postępowanie w przypadku zakażenia wirusem brodawczaka ludzkiego

HPV – profilaktyka i postępowanie w przypadku zakażenia wirusem brodawczaka ludzkiego

Kilka informacji podstawowych

– HPV jest jednym z najpopularniejszych wirusów przenoszonych drogą płciową
– większość ludzi nie zdaje sobie sprawy, że posiada wirusa HPV
– istnieje ogromna ilość odmian HPV i nie ma szybkich i tanich testów na HPV
– HPV niskiego ryzyka wywołuje “genital warts” czyli brodawki/narośla na narządach płciowych
– HPV wysokiego ryzyka wywołuje raka (w narządach płciowych, gardle etc.)
– HPV można zarazić się nawet kiedy używasz prezerwatyw
– HPV można zarazić się w trakcie seksu oralnego (mineta, blowjob)
– w większości przypadków HPV nie daje żadnych objawów, więc ludzie nie wiedzą, że go mają (w tym czasie mogą zarażać inne osoby)
– nie ma leku na HPV – leczyć można tylko jego objawy
– istnieją szczepionki na HPV – na przykład Gardasil i Gardasil 9
– system immunologiczny zazwyczaj radzi sobie z HPV w czasie max. 2 lat.
– jeśli system immunologiczny jest silny, to HPV chowa się w komórkach i siedzi cicho
– jeśli system immunologiczny jest słaby, to HPV atakuje z ogromną siłą
– HPV odpowiada za 25%-35% przypadków raka gardła
– HPV odpowiada za ogromną ilość przypadków raka kobiecych narządów płciowych

Zapobieganie

Na chwile obecną najsensowniejszą formą obrony przed HPV jest zaszczepienie się. Najskuteczniejsze szczepionki to Gardasil (chroni przed 4 najpopularniejszymi szczepami) i Gardasil 9 (chroni przed 9 najpopularniejszymi szczepami). Szczepionka jest skuteczna już po 2 injekcjach, chociaż formalnie powinno się zrobić 3. Niestety koszt szczepienia jest drogi (250-300zł za jedno szczepienie).

Do tego warto stosować prezerwatywy (chociaż nie ochronią całych narządów płciowych) i warto pamiętać, że HPV można dostać w przypadku seksu oralnego. W ten sposób Michael Douglas nabawił się raka gardła.

Leczenie objawów

* Po pierwsze idź do lekarza i poproś o przeprowadzanie testu krwi pod kątem cukrzycy. Istnieje korelacja między siła/nawrotami kłykcin HPV a cukrzycą. Jeśli masz cukrzycę to zacznij się leczyć lub/i przejdź na dietę niskowęglowodanową *

Tak jak wspominałem – nie ma leku na HPV. I niestety wielkie korpo raczej mają gdzieś szukanie go. Na chwile obecną skupiają się na szczepionkach przeciwko HPV i produkowaniu drogich kremów na kłykciny na narządach płciowych.

W przypadku raka wywołanego przez HPV leczenie jest typowe dla… leczenia raka.

W przypadku genital warts możliwości jest kilka. Z jednej strony mamy środki stosowane przez lekarzy w szpitalach/klinikach medycznych:
– elektrokauteryzacja, czyli wypalanie za pomocą ładunków elektrycznych
– wymrażanie za pomocą liquid nitrogen
– wypalanie laserem
– wypalenie za pomocą kwasu

Z drugiej strony mamy środki których można używać w warunkach domowych:
– Imiquimod, immunomodulator, drogi krem który wysyła sygnał do systemu immunologicznego, że w danym miejscu coś jest nie tak
– Veregen, bardzo drogi krem na bazie zielonej herbaty, który skutecznie (ale powoli) wytruwa narośla z HPV
– Podhopyllotoxin (w Polsce znany pod nazwą generyczną Condyline), toksyna która wytruwa wirusa HPV z narośli
– jest jeszcze kwas salicylowy 20% ale jego skuteczność jest minimalna, ok. 28%

Jeśli interesuje Was skuteczność poszczególnych metod, to polecam to podsumowanie:
https://www.cdc.gov/std/tg2015/evidence-tables/hpvtableevidence-genitalwarts-2015.pdf

Ale uwaga – wszystkie w/w metody mają jedną główną wadę: atakują tylko “efekty” działania wirusa, natomiast ten wirus który siedzi w skórze (a którego nie widać w danym momencie), ma się dobrze. Nawroty w przypadku w/w metod wachają się między 20% a 40%.

Czy istnieje jakaś skuteczniejsza metoda wybijania wirusa HPV?

Tak. Istnieje. Nazywa się “Photodynamic Therapy” i ma ogromną skuteczność oraz niski % nawrotów. Jak to działa? Ano narządy płciowe smaruje się kwasem 5-aminolevulinic i pozostawia na 3 godziny. W tym czasie w/w kwas wnika w skórę i – w dużym skrócie – zdrowe komórki szybko się go pozbywają, a w chorych komórkach pozostaje na dłużej. Tak więc po wspomnianych 3 godzinach przystawia się czerwony laser na 10-20 minut, i w tym momencie dochodzi do reakcji fotochemicznej która zabija wirusa i komórki z wirusem.

Hurra powiecie? Prawie. Problem polega na tym, że ALA-PDT (taka jest skrótowa nazwa tej terapii) stosuje się np. na twarz i ACNE. Więc większość lekarzy/klinik/szpitali nie ma ochoty ani wiedzy, żeby zastosować ALA-PDT na genital warts. Większość badań klinicznych n/t ALA-PDT vs. genital warts pochodzi z Chin, bo chyba tylko tam mają wystarczająco duże jaja, żeby sprawdzać wszystkie metody lecznicze.

Badania kliniczne na temat ALA-PDT vs. genital warts:
https://www.ncbi.nlm.nih.gov/pubmed/17975355
https://www.ncbi.nlm.nih.gov/pubmed/21271995
https://www.ncbi.nlm.nih.gov/pubmed/27648048

Polecam tego PDF’a na temat terapii fotodynamicznej, punkt 6.6:
http://www.euroderm.org/edf/index.php/edf-guidelines/category/5-guidelines-miscellaneous?download=43:guideline-photodynamic-therapy

Wzmocnienie systemu immunologicznego

Mając HPV warto pamiętać o wzmacnianiu systemu immunologicznego. Jednym ze sposobów jest przyjmowanie 3-6 gram dziennie (rano, na pusty żołądek) ekstraktu z grzyba Coriolus versicolor (znanego też jako Trametes versicolor). Jest to jeden z grzybów lecznicznych który jest stosowany przez np. osoby po chemioterapii, a który skutecznie wzmacnia układ odporności i przyśpiesza walkę układu immunologicznego z wirusem HPV.

Coriolus versicolor a liczba Natural Killer cells: http://www.atmph.org/article.asp?issn=1755-6783;year=2016;volume=9;issue=5;spage=360;epage=361;aulast=Chaiyasit
Coriolus versicolor i reishi a oralny HPV https://www.ncbi.nlm.nih.gov/pubmed/25271984
Coriolus versicolor a wirus HPV http://www.positivehealth.com/article/cancer/coriolus-versicolor-as-an-effective-addition-to-the-treatment-of-hpv-infection

Także grzyb Reishi skutecznie zwalcza wirusa HPV, chociaż wg. źródeł internetowych w formie “ekstraktu” nie powinno się go przyjmować dłużej niż 1 miesiąc. Natomiast w przypadku “kapsułek” – nie ma żadnych ograniczeń.

Niestety suplementy diety z grzybami medycznymi są bardzo drogie (jeśli weźmiemy zalecaną dawkę 3-6g dziennie) dlatego najlepiej kupić 1kg wybranego ekstraktu wprost od producenta, np. z Chin. Ze swojej strony polecam firmę Nate Bio-tech, http://www.natesw.com, której ofertę znajdziecie również na portalu Alibaba.

Podsumowując:

Jeśli nie masz HPV to polecam zaszczepienie się tak szybko jak to tylko możliwe. Natomiast jeśli masz już HPV, to również polecam zaszczepienie się, wzmacnianie organizmu za pomocą ekstraktu z Coriolus versicolor, a w przypadku genital warts: stosowanie Podophyllotoxin, wymrażanie za pomocą liquid nitrogen lub – jeśli to możliwe – skorzystanie z terapii ALA-PDT.

I pamiętajcie, że HPV można zarazić się także w trakcie seksu oralnego.

HPV treatment – HPV cure research 2018

Prologue: How to deal with HPV?

A) Don’t PANIC!
B) Learn about HPV from reliable sources, for example:
https://www.cdc.gov/vaccines/pubs/surv-manual/chpt05-hpv.html
C) Don’t waste your money on food supplements without any clinical trials (like Echinacea, Astralagus, Zinc…)
D) REALLY DON’T PANIC 🙂

There is no cure for HPV but you can still fight with the virus.

How to get rid of HPV faster?

1) Quit smoking
2) Quit drinking
3) Check glucose level in your blood – there is a correlation between HPV strength/recurrence of genital warts (if you have HPV6/11) and diabetes.
4) Eat healthy food, eat lots of vegetables
5) Lower your sugar/carbohydrates intake. Cancer and HPV love sugar.
6) Exercise 2-3 times per week
7) Start taking medicinal mushrooms (at least 1):
– Coriolus versicolor boost immune system
– Reishi fights directly with HPV* and cancer cells*
– Chaga has strong anti-viral activity

IMPORTANT: buy only alcohol/water reishi extracts because they have active ingredients. Avoid powdered reishi – it’s not better than placebo.

– Lentinan (from shiitake mushrooms) lowers genital warts recurrence

* – In this study, we investigated the effects of the aqueous extracts of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum, obtained from three localities (China; and Morelos and Michoacan, Mexico) on cervical cells transformed by human papillomavirus (HeLa and SiHa) and C-33A cancer cells. The cells were plated in DMEM medium supplemented, and were incubated in the presence of different concentrations of G. lucidum for 24 h. Cell proliferation was determined by MTT colorimetric assay and viability by trypan blue assay. Inhibitory dose was determined (IC50) of the three different extracts of G. lucidum in the culture cell lines mentioned above. The apoptosis process was confirmed by nuclear DNA fragmentation and the cell cycle was determined by flow cytometry. The results showed that aqueous extracts G. lucidum obtained from three localities produced inhibition in the proliferation of VPH transformed cells; they also induced apoptosis and cell cycle arrest in HeLa, SiHa, and C-33A cancer cells. Therefore, it was found that aqueous extracts G. lucidum obtained from three different locations produced inhibitory effect on cancer cells and may have a potential therapeutic use for the prevention and treatment of this disease.

8) Vaccine yourself against HPV – it will not help your current infection, but it can protect you against other HPV strains. The best vaccine is called “Gardasil” and “Gardasil 9”.

How to get rid of genital warts?

You can try:
– Podophyllotoxin (it’s very effective, very fast, but you can get skin infection)
– Imiquimod/Aldara (it’s an immunomodulator, you will wait longer to see the effects; Imiquimod is much less effective in case of men)
– Veregen (it’s a green tea extract, it’s effective but very expensive; you will wait very long to see the effects)
– Panavir (antiviral medicine made in Russia; it’s available i.e. as a gel)

You can ask your doctor for:
– electrocauterization (it’s painful)
– laser treatment
– cryotherapy (the fastest and the cheapest option)
– photodynamic therapy (the best option but it’s hard to get photodynamic therapy against genital warts; many dermatologists don’t know that photodynamic therapy can be used against genital warts)

In general the best options for HPV are:
– check your glucose level and avoid junk food/sugar
– take medicinal mushrooms – Coriolus versicolor 3g/daily in the morning, Reishi (Lingzhi) 1-2g/daily in the evening.
http://dl.begellhouse.com/journals/708ae68d64b17c52,266d4152107fca7a,3512deba5cc9e72b.html
– take Ellagic acid and Annona Muricata extract (check details below)

In general the best options for HPV genital warts are as above, and additionally:
– use Podophyllotoxin for small warts
– use Cryotherapy for big warts
– try to get Photodynamic Therapy
– try Panavir, it’s very effective in combined therapy, when i.e. Cryotherapy removes the warts, and Panavir lowers the chances of recurrences

YOU CAN BUY PANAVIR AT OTC ONLINE STORE

2018 UPDATE:

Hyperthermia vs. HPV and genital warts

In the current report, the investigators demonstrate that APOBEC3A and APOBEC3G expression levels are increased in genital warts (condyloma acuminata) compared with normal tissues, in which APOBEC3G is barely detectable (Yang et al., 2017). On heat treatment to 42 °C and 45 °C, there is a significant increase in APOBEC3A and APOBEC3G mRNA transcripts in condyloma acuminate, up to 10-fold. Again, this effect is not observed in normal skin.

Although hyperthermia is not as widely used as cryotherapy in treating warts, including genital warts, it is interesting to note that hyperthermia seems to have an advantage as it is not destructive, but, rather, appears to stimulate antiviral and immunological pathways that are reminiscent of the use of imiquimod. This study provides an elegant explanation for the observed clinical effects of hyperthermia on warts. What is unclear is whether APOBEC3A and APOBEC3G expression contribute not only to editing HPV and limiting its replication, but also whether these mutations increase immune responses against the virus. Hyperthermia, in contrast to cryotherapy, would be an elegant way to expose the virus in a meaningful way to immune reactivity and even prevent recurrences, an effect similar to that of imiquimod when used to treat genital warts.

http://www.sciencedirect.com/science/article/pii/S0022202X17301033

Ellagic acid and Annona Muricata vs. HPV and L-SIL

Ellagic acid (EA) and Annona Muricata (AM) have antioxidant, anticarcinogenic and antiviral activity demonstrated by in vitro models. This pilot study investigated the in vivo potential anti-viral activity in women affected by Low squamous intraepithelial lesion (L-SIL) related to high risk human papilloma virus (HR-HPV), and the ability to modify the oncoproteins expression in the cervical lesion thickness. Sixty women affected by HR-HPV related L-SIL, were randomly divided into two groups: group A (n = 30) supplemented with EA (16 mg) + AM (100 mg) 2 times daily for 6 months and group B (n = 30) administered with placebo. HR-HPV clearance was obtained in 74% of cases in group A compared to 25% of cases in group B (p = 0.001) and p21 expression in LSIL thickness increased in 63.2% of cases in group A compared to 20% in group B (p = 0.03). AE/AM supplementation significantly induces HR-HPV elimination and stimulates p21 expression in LSIL thickness.

http://www.sciencedirect.com/science/article/pii/S1756464617303225

2018 UPDATE 2:

Check clinical trials about Panavir, antiviral medicine made in Russia:

http://poi555.com/2018/01/panavir-from-russia-alternative-treatment-for-hpv-and-genital-warts/

YOU CAN BUY PANAVIR AT OTC ONLINE STORE

Lentinan from shiitake mushrooms vs. HPV

Objective: To observe the immunomodulatory and therapeutic effect of lentinan in treating condyloma acuminatum (CA).Methods: Thirty-six CA patients were randomly divided into two groups, 19 in the treated group treated with lentinan and CO2 laser irradiation, and 17 in the control group, treated with laser irradiation alone. Their T lymphocyte subsets of peripheral blood and level of serum interleukin-2 (IL-2) and soluble interleukin-2 receptor (SIL-2R) were determined before and after treatment, and the recurrence rates of the two groups were compared.Results: After treatment, in the treated group, the CD4/CD8 ratio, serum IL-2 raised and serum SIL-2R lowered significantly (P < 0.05, 0.05, 0.05 respectively) as compared with before treatment, while those parameters were not changed significantly in the control group. The recurrence rate of the treated group was lower than that of the control group.P < 0.05.Conclusion: Lentinan could modulate the cellular immunofunction of CA patients and reduce the recurrence rate of CA cases.

Comparison of Recurrence Rate of Two Groups after Treatment:

Ten among 36 cases showed recurrence, the recurrence rate was 27.78%; among them, 2 of the treated group were recurrent, the recurrence rate was 10.53%; while that of the control group [the recurrence rate] was 47.06% (8/17 cases). The difference of the recurrence rate of two groups was significiant.

Check the whole clinical trial: Immunomodulatory and therapeutic effect of lentinan in treating condyloma acuminatum

The best hospital in Bangkok – King Chulalongkorn Memorial Hospital

King Chulalongkorn Memorial Hospital is one of the best and the cheapest hospitals in Bangkok and Thailand. It’s operated by Thai Red Cross Society, and serves as the teaching hospital for the Faculty of Medicine at Chulalongkorn University.

Chulalongkorn Hospital has such clinics as:
– dentistry,
– forensic medicine,
– internal medicine,
– orthopedics,
– pediatrics,
– preventive medicine,
– psychiatry,
– obstetrics and gynecology,
– ophthalmology,
– otolaryngology,
– radiology,
– dermatology,
– surgery.

King Chulalongkorn Memorial Hospital is located next to Silom MRT station / Sala Daeng BTS station / Lumpini park. You can’t miss it.

King Chulalongkorn Memorial Hospital is much cheaper than private hospitals, however for the 1st time you should come in the morning and bring your passport. Remember to take queue number as soon as possible. Nurses at Chulalongkorn Hospital usually speak English, so don’t worry and ask them for guidance.

LIFE HACK #1

If it’s your 1st time at Chulalongkorn Hospital, then ask for appointment to the general doctor. Queue should be short and general doctor will give you advice and appointments to other doctors.

LIFE HACK #2

Morning clinics are cheaper than evening clinics, however in the morning you will have to wait a few hours in queues. So if you don’t want to spend too much time in queues – ask for the appointment in the evening.

LIFE HACK #3

Always ask for the appointment for the next visit OR appointment to another doctor. This small piece of paper can save you lots of time.

Medicinal mushrooms and cancer – a scientific review

From time immemorial, mushrooms have been valued by humankind as a culinary wonder and folk medicine in Oriental practice. The last decade has witnessed the overwhelming interest of western research fraternity in pharmaceutical potential of mushrooms. The chief medicinal uses of mushrooms discovered so far are as anti-oxidant, anti-diabetic, hypocholesterolemic, anti-tumor, anti-cancer, immunomodulatory, anti-allergic, nephroprotective, and anti-microbial agents. The mushrooms credited with success against cancer belong to the genus Phellinus, Pleurotus, Agaricus, Ganoderma, Clitocybe, Antrodia, Trametes, Cordyceps, Xerocomus, Calvatia, Schizophyllum, Flammulina, Suillus, Inonotus, Inocybe, Funlia, Lactarius, Albatrellus, Russula, and Fomes. The anti-cancer compounds play crucial role as reactive oxygen species inducer, mitotic kinase inhibitor, anti-mitotic, angiogenesis inhibitor, topoisomerase inhibitor, leading to apoptosis, and eventually checking cancer proliferation. The present review updates the recent findings on the pharmacologically active compounds, their anti-tumor potential, and underlying mechanism of biological action in order to raise awareness for further investigations to develop cancer therapeutics from mushrooms. The mounting evidences from various research groups across the globe, regarding anti-tumor application of mushroom extracts unarguably make it a fast-track research area worth mass attention.

Read the whole raport: Recent developments in mushrooms as anti-cancer therapeutics: a review

The best medicinal mushrooms – list, benefits, anti-cancer mushrooms

TOP MEDICINAL MUSHROOMS

  • Reishi
  • Coriolus versicolor
  • Shiitake
  • Monkeyhead mushroom
  • Agaricus blazei
  • Chaga
  • Cordyceps sinensis

Reishi extract

LATIN NAME:
Ganoderma lucideum

PART USED:
Fruitbody, Mycelium

ACTIVE INGREDIENTS:
Polysaccharides, BETA D Glucan, Triterpene, Protein, Reishi acid

PHARMACOLOGICAL ACTION:
Anti-tumor
Protect liver
Anti-aging
Anti-allergic
Strengthen immunity
Promote the synthetic ability of DNA, RNA and protein in the liver, bone marrow and blood

Lions mane / Monkeyhead mushroom extract

LATIN NAME:
Hericium erinaceus

PART USED:
Fruitbody, mycelium

ACTIVE INGREDIENTS:
Polysaccharides, BETA D Glucan, Hericenones

PHARMACOLOGICAL ACTION:
Help to cure dyspesia, gastric ulcer, stomachache gasteremphraxis and neurasthenia
Lower serum cholesterol
Promote blood circulation

Agaricus blazei extract

LATIN NAME:
Agaricus brasilensis

PART USED:
Fruitbody, mycelium

ACTIVE INGREDIENTS:
Polysaccharides, BETA D Glucan, Triterpene, Glycopeptide

PHARMACOLOGICAL ACTION:
Retrain tumor cell growth
Lower blood glucose and cholesterol
Reverse atherosclerosis
Anti-tumor, anti-radiation
Resist mutation and anti-inflammatory

Coriolus versicolor / Turkey Tail

LATIN NAME:
Trametes versicolor

PART USED:
Fruitbody, mycelium

ACTIVE INGREDIENTS:
Polysaccharides, BETA D Glucan, Triterpene, Glycopeptite, Protein

PHARMACOLOGICAL ACTION:
Protect liver and heart
Cure chronic hepatitis and hepatitis B
Anti-aging
Anti-oxidant
Anti-tumor
Enhance body immunity

Shiitake extract

LATIN NAME:
Lentinus edodes

PART USED:
Fruitbody, Mycelium

ACTIVE INGREDIENTS:
Polysaccharides, BETA D Glucan, Adenosine

PHARMACOLOGICAL ACTION:
Relieve symptoms of relapsed gastric cancer, liver cancer, bladder canber.
Enhance body immunity system.
Adjust disorder of trace emements.

Chaga extract

LATIN NAME:
Inonqqus obliquus

PART USED:
Fruitbody, mycelium

ACTIVE INGREDIENTS:
Polysccharides, BETA D Glucan, Triterpene, Betulinic acid

PHARMACOLOGICAL ACTION:
Lower blood glucose
Help to cure heart diseases, diabetes, cancer (gastric cancer, liver cancer, lung cancer)
Restrain HIV virus

Cordyceps sinensis extract

LATIN NAME:
Ophiocordyceps sinensis

PART USED:
Mycelium, dried cordyceps militaris

ACTIVE INGREDIENTS:
Polysaccharides, Manitol, Adenosine, Cordycepin, Cordycepic acid

PHARMACOLOGICAL ACTION:
Improve respiratory system
Enhance body immunity
Promote adrenal gland
Anti-tumor

Can low-carbohydrate diet cure type 2 diabetes?

Can low-carbohydrate diet cure type 2 diabetes?

It seems so:

At the first visit, participants were instructed how to follow the LCKD as individuals or in small groups, with an initial goal of ≤20 g carbohydrate per day. Participants were taught the specific types and amounts of foods they could eat, as well as foods to avoid. Initially, participants were allowed unlimited amounts of meats, poultry, fish, shellfish, and eggs; 2 cups of salad vegetables per day; 1 cup of low-carbohydrate vegetables per day; 4 ounces of hard cheese; and limited amounts of cream, avocado, olives, and lemon juice. Fats and oils were not restricted except that intake of trans fats was to be minimized. Participants were provided a 3-page handout and a handbook detailing these recommendations. Participants prepared or bought all of their own meals and snacks following these guidelines.

Twenty-one of the 28 participants who were enrolled completed the study. Twenty participants were men; 13 were White, 8 were African-American. The mean [± SD] age was 56.0 ± 7.9 years and BMI was 42.2 ± 5.8 kg/m2. Hemoglobin A1c decreased by 16% from 7.5 ± 1.4% to 6.3 ± 1.0% (p < 0.001) from baseline to week 16. Diabetes medications were discontinued in 7 participants, reduced in 10 participants, and unchanged in 4 participants. The mean body weight decreased by 6.6% from 131.4 ± 18.3 kg to 122.7 ± 18.9 kg (p < 0.001). In linear regression analyses, weight change at 16 weeks did not predict change in hemoglobin A1c. Fasting serum triglyceride decreased 42% from 2.69 ± 2.87 mmol/L to 1.57 ± 1.38 mmol/L (p = 0.001) while other serum lipid measurements did not change significantly.

Read the whole raport from the clinical trial: A low-carbohydrate, ketogenic diet to treat type 2 diabetes

Medicinal mushrooms vs. cancer – clinical trials

This review discusses the immunological roles of 5 major mushrooms in oncology: Agaricus blazei, Cordyceps sinensis, Grifola frondosa, Ganoderma lucidum, and Trametes versicolor. These mushrooms were selected based on the body of research performed on mushroom immunology in an oncology model. First, this article focuses on how mushrooms modify cytokines within specific cancer models and on how those cytokines affect the disease process. Second, this article examines the direct effect of mushrooms on cancer. Finally, this article presents an analysis of how mushrooms interact with chemotherapeutic agents, including their effects on its efficacy and on the myelosuppression that results from it. For these 5 mushrooms, an abundance of in vitro evidence exists that elucidates the anticancer immunological mechanisms. Preliminary research in humans is also available and is promising for treatment.

Summary of potential clinical applications of medicinal mushrooms:

Type of Cancer Indicated Mushroom
Nonsmall-cell lung cancer Cordyceps
Lung cancer Reishi (ganorderma lucidum)
Gastric cancer PSK (turkey tail/coriolus versicolor)
Hepatocellular carcinoma Agaricus, reishi (ganoderma lucidum)
Leukemia Agaricus, reishi (ganoderma lucidum)
Lymphoma Cordyceps
Breast cancer Reishi, maitake, turkey tail (Coriolus versicolor)
Colon cancer Maitake, reishi, turkey tail (Coriolus versicolor)
Prostate cancer Reishi (ganoderma lucidum)
Sarcoma Reishi (ganoderma lucidum)

Abbreviations:
PSK = polysaccharide K.
Turkey tail = Coriolus versicolor = Trametes versicolor
Reishi = Ganoderma lucidum

Check the whole review below:

Source: Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology

How to cure HPV genital warts with Photodynamic therapy

Photodynamic therapy (ALA-PDT) is usually used against ACNE, but it’s off label usage (against genital warts) is very effective and has very low reccurence rate.

Study 1:

The patient, a 30-year-old man with numerous genital condylomata acuminata (CA), has had unsuccessful treatment with liquid nitrogen, 20% podophyllin, and repeated 0.5% podophyllotoxin solution with 5% imiquimod (Figure 1). Before the appearance of CA, he experienced acute orchiepididimitis and a Candida infection. The patient was immunologically examined, and the lower level of lymphocytes, slightly reduced level of IgM, and C4 complement were revealed. Results from a human immunodeficiency virus examination were negative. After the therapeutic failure mentioned above, photodynamic therapy (PDT) was initiated using 20% aminolevulinic acid (5-ALA) in a gel. The photosensitizer was applied to lesions and 10 mm of surrounding skin in a 1-mm-thick layer under occlusive dressing for 3 hours and then removed with saline and nonwoven gauze. The site was immediately irradiated with noncoherent red light with an emission spectrum of 580 to 680 nm wavelength (Medeikonos PDT-Model 200, Medeikonos AB, Sweden). The total light dose was 50 J/cm(2); light intensity ranged from 70 to 90 mW/cm(2). Because of persistent fluorescence during photodynamic therapy, the treatment was repeated 10 times in 2-week intervals with a follow-up of 1, 3, and 6 months after its completion. After the last PDT treatment, the persistent fluorescence disappeared completely. The absence of fluorescence corresponded with a healed clinical finding without scarring and pigmentation (Figure 2). The period from the initiation of PDT to the consolidation of CA was 22 weeks. During PDT treatment, the patient felt only mild burning, which disappeared after the illumination stopped. Six months after the therapy, there were no signs of recurrent disease.

Source: Genital warts treated by photodynamic therapy.

Study 2:

Our trial provided a complete cure rate of nine of 15 subjects after five PDT sessions. Perianal lesions showed a particularly rapid remission. While progressing towards total lesion clearance, the immunohistochemical pattern was dominated by dense CD4+ T lymphocytes infiltrating the superficial dermis, accompanied by an accumulation of Langerhans cells. Simultaneously, CD8 began to increase in the lesions of responding patients, and Langerhans cells seemed to migrate towards the dermis. CD68+ macrophages apparently did not participate in the immune inflammatory response.

Source: Immunological activity of photodynamic therapy for genital warts.

Study 3:

Genital warts were relieved in 107 out of the 110 cases (cure rate: 97.3%). Male patients had significantly better treatment outcomes at the urethral orifice than those in other affected parts. In the 107 patients, the cure rate of male patients was 98.8%, and they were cured after being treated four times. In contrast, female patients, who were cured after 5 times of treatment, had the cure rate of 91.7%. Their cure rates were similar (χ(2)=0, P>0.05), but the males were cured after significantly fewer times of treatment than the females (t=-7.432, P<0.05). Five patients suffered from mild tingling or burning sensation upon dressing at the urethral orifice, and the others were all free from systemic adverse reactions. After illumination, a small portion of the patients had mildly red, swelling, painful affected parts, with mild edema that almost disappeared within three days. Three patients relapsed at the urethral orifice and were then cured after further treatment.

Source: Therapeutic effects of topical 5-aminolevulinic acid photodynamic therapy.

European Dermatology Forum about Photodynamic therapy:

Download PDF file and look at point 6.6

Check other clinical studies about Photodynamic therapy vs. genital warts:

Download PDF file

Coriolus versicolor vs. HPV – clinical trials

Study 1:

In the conservative treatment, 64 out of 73 patients (88% of total) reverted to HPV-negative status;
In the combined treatment, 25 out of 27 patients (93% of total)reverted to HPV-negative status;

Study 2:

95% of the patients reverted to HPV-negative status within 6 months;
HPV-positive patients without histological changes reverted to HPV-negative status in 3 months;

Study 3:

Dr Couto showed that Coriolus versicolor biomass supplementation (3 g per day) over a period of one year substantially increased regression of LSIL (72.5% versus control 47.5%) and induced clearance of the high-risk sub-types of the HPV virus responsible for cervical cancer (90.0% versus control 8.5%).

Check this website for more details: Coriolus versicolor as an Effective Addition to the Treatment of HPV Infection

Study 4:

Effect of tropical mushroom, Coriolus versicolor, on natural killer cell

Here, the authors report observation on a patient with underlying breast cancer after complete standard treatment who intake C. versicolor as food supplementation. At first, her natural killer count (CD16/56) was at 5.9% (normal value 6.4-31.1). She got C. versicolor 2400 mg/day for 1 month, and the follow-up result showed CD16/56 equal to 11.6%. This observation can support the findings that C. versicolor could promote immunity.

Source: Annals of Tropical Medicine and Public Health