Lentinan from shiitake mushrooms vs. HPV

Objective: To observe the immunomodulatory and therapeutic effect of lentinan in treating condyloma acuminatum (CA).Methods: Thirty-six CA patients were randomly divided into two groups, 19 in the treated group treated with lentinan and CO2 laser irradiation, and 17 in the control group, treated with laser irradiation alone. Their T lymphocyte subsets of peripheral blood and level of serum interleukin-2 (IL-2) and soluble interleukin-2 receptor (SIL-2R) were determined before and after treatment, and the recurrence rates of the two groups were compared.Results: After treatment, in the treated group, the CD4/CD8 ratio, serum IL-2 raised and serum SIL-2R lowered significantly (P < 0.05, 0.05, 0.05 respectively) as compared with before treatment, while those parameters were not changed significantly in the control group. The recurrence rate of the treated group was lower than that of the control group.P < 0.05.Conclusion: Lentinan could modulate the cellular immunofunction of CA patients and reduce the recurrence rate of CA cases.

Comparison of Recurrence Rate of Two Groups after Treatment:

Ten among 36 cases showed recurrence, the recurrence rate was 27.78%; among them, 2 of the treated group were recurrent, the recurrence rate was 10.53%; while that of the control group [the recurrence rate] was 47.06% (8/17 cases). The difference of the recurrence rate of two groups was significiant.

Check the whole clinical trial: Immunomodulatory and therapeutic effect of lentinan in treating condyloma acuminatum